[HTML][HTML] High-resolution mapping of linear antibody epitopes using ultrahigh-density peptide microarrays

S Buus, J Rockberg, B Forsström, P Nilsson… - Molecular & Cellular …, 2012 - ASBMB
Antibodies empower numerous important scientific, clinical, diagnostic, and industrial
applications. Ideally, the epitope (s) targeted by an antibody should be identified and
characterized, thereby establishing antibody reactivity, highlighting possible cross-
reactivities, and perhaps even warning against unwanted (eg autoimmune) reactivities.
Antibodies target proteins as either conformational or linear epitopes. The latter are typically
probed with peptides, but the cost of peptide screening programs tends to prohibit …