B cell‐deficient μMT mice as an experimental model for Mycoplasma infections in X‐linked agammaglobulinemia
A Berglöf, K Sandstedt, R Feinstein… - European journal of …, 1997 - Wiley Online Library
A Berglöf, K Sandstedt, R Feinstein, G Bölske, CIE Smith
European journal of immunology, 1997•Wiley Online LibraryB cell‐deficient μMT mice were investigated as an experimental model for human X‐linked
agammaglobulinemia (XLA). Mice were intranasally infected with Mycoplasma pulmonis
and in 16 out of 17 μMT mice, dissemination of the bacteria from the airways was observed.
More than 50% of these mice developed arthritis and/or changes in periarticular tissues.
Mycoplasmal infection in μMT mice thus resembles the disease seen in XLA patients
implying the usefulness of the model.
agammaglobulinemia (XLA). Mice were intranasally infected with Mycoplasma pulmonis
and in 16 out of 17 μMT mice, dissemination of the bacteria from the airways was observed.
More than 50% of these mice developed arthritis and/or changes in periarticular tissues.
Mycoplasmal infection in μMT mice thus resembles the disease seen in XLA patients
implying the usefulness of the model.
Abstract
B cell‐deficient μMT mice were investigated as an experimental model for human X‐linked agammaglobulinemia (XLA). Mice were intranasally infected with Mycoplasma pulmonis and in 16 out of 17 μMT mice, dissemination of the bacteria from the airways was observed. More than 50% of these mice developed arthritis and/or changes in periarticular tissues. Mycoplasmal infection in μMT mice thus resembles the disease seen in XLA patients implying the usefulness of the model.
Wiley Online Library