Broad defects in epidermal cornification in atopic dermatitis identified through genomic analysis

E Guttman-Yassky, M Suárez-Fariñas… - Journal of Allergy and …, 2009 - Elsevier
BACKGROUND: Psoriasis and atopic dermatitis (AD) are common, complex inflammatory
skin diseases. Both diseases display immune infiltrates in lesions and epidermal
growth/differentiation alterations associated with a defective skin barrier. An incomplete
understanding of differences between these diseases makes it difficult to compare human
disease pathology to animal disease models. OBJECTIVE: To characterize differences
between these diseases in expression of genes related to epidermal growth/differentiation …